mTOR Phospho Antibody Array
The mechanistic target of rapamycin (mTOR) is a serine-threonine protein kinase that regulates cell growth, cell proliferation, protein synthesis, and autophagy. Abnormal mTOR signaling has been associated with neurological disorders, cancer, and diabetes. mTOR forms two distinct complexes: mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2). mTOR binds with the regulatory protein raptor and other binding proteins to form mTORC1 while it binds with regulatory protein rictor and other proteins to form mTORC2. mTORC1 phosphorylates p70S6K and eIF4E to promote mRNA translation and protein synthesis. Growth factors such as insulin trigger the AKT pathway, which signals downstream to mTORC1 to promote cell growth and inhibit autophagy. Oppositely, nutrient deprivation and low energy levels activate the AMPK pathway, which inhibits mTORC1, thus restricting cell growth and promoting autophagy. mTORC2 can affect metabolism and cell survival through phosphorylation of AKT. mTORC2 regulates the cytoskeleton through PKC alpha activation and also influences ion transport.
mTOR Phospho Antibody Array is a high-throughput ELISA based antibody array for qualitative protein phosphorylation profiling. It is suitable for comparing normal samples to treated or diseased samples, and identifying candidate biomarkers. This array features site-specific and phospho-specific antibodies, allowing researchers to study tyrosine, serine, and threonine phosphorylation at specific sites.
Key Features
- Site-specific phosphorylation profiling and screening
- Suitable samples include: cell lysates; frozen or FFPE tissue lysates
- Glass based array with high specificity and low background
- Antibodies covalently attached to 3D polymer coated glass surface
- Sensitive fluorescent detection
User’s Guide
Antibody Array User’s Guide
Product Details
| Number of Antibodies: | 138 site-specific and phospho-specific antibodies; 6 replicates per antibody |
| Target List: | Antibody List |
| Reactivity: | Human: 100%; Mouse: 97%; Rat: 83% |
| Internal Controls: | beta-actin; GAPDH; Negative controls |
| Detection Method: | Fluorescence; Compatible Scanners |
| Slide dimensions: | 76 x 25 x 1 mm |
| Product Size: | 2 array slides per package for analyzing two samples (control vs. treated) |
| Storage Condition: | 4°C for 6 months |
Additional Reagent Needed:
Antibody Array Assay Kit
$350.00
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