TGF-beta Phospho Antibody Array
Transforming growth factor beta (TGF-β) signaling plays an important role in cell proliferation, differentiation, and repair of many organisms. The signaling process begins with a dimeric TGF-β superfamily ligand binding to a Type II receptor, which enlists a Type I receptor (TGFBR1) and phosphorylates its serine residues. The activated TGFBR1 then phosphorylates and activates cytoplasmic molecules Smad2 and Smad3 for the TGF-β pathway or Smad1/5/9 for the bone morphogenetic protein (BMP) pathway. The phosphorylation of Smads leads to formation of a hetero-oligomeric complex with Smad4, which then moves into the nucleus and interacts with transcription promoters/cofactors and regulates gene expression. TGF-β also participates in the regulation of non-Smad pathways including ERK1/2, JNK/SAPK, and p38 MAP kinase pathways.
TGF-β (TGF-beta) Phospho Antibody Array is a high-throughput ELISA based antibody array for qualitative protein phosphorylation profiling. It is suitable for comparing normal samples to treated or diseased samples, and identifying candidate biomarkers. This array features site-specific and phospho-specific antibodies, allowing researchers to investigate serine/threonine and tyrosine phosphorylation at specific sites.
Key Features
- Site-specific phosphorylation profiling and screening
- Suitable samples include: cell lysates; frozen or FFPE tissue lysates
- Glass based array with high specificity and low background
- Antibodies covalently attached to 3D polymer coated glass surface
- Sensitive fluorescent detection
User’s Guide
Antibody Array User’s Guide
Product Details
| Number of Antibodies: | 176 site-specific and phospho-specific antibodies; 6 replicates per antibody |
| Target List: | Array Antibody List |
| Reactivity: | Human: 100%; Mouse: 97%; Rat: 87% |
| Internal Controls: | beta-actin; GAPDH; Negative controls |
| Detection Method: | Fluorescence; Compatible Scanners |
| Slide dimensions: | 76 x 25 x 1 mm |
| Product Size: | 2 array slides per package for analyzing two samples (control vs. treated) |
| Storage Condition: | 4°C for 6 months |
Additional Reagent Needed:
Antibody Array Assay Kit
$350.00
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